We're allowing hundreds of thousands to pour over the Southern Border from South America, where the Lambda variant is dominant. Keep that in mind when you read the rest of this.
The title of this new paper speaks for itself: "SARS-CoV-2 Lambda variant exhibits higher infectivity and immune resistance"
Notable here, is the case of Chile, where the vaccination rate is relatively high. The percentage who received at least one dose of COVID-19 vaccine was ~60% on June 1, 2021."
However, the new study focuses on vaccination, not natural immunity, and how the Lambda variant is so "proficient in escaping from the antiviral immunity elicited by vaccination."
The same is also true of the Delta variant.
Researchers prepared the viruses pseudotyped with the S proteins of the Lambda variant as well as four variants of concerns (VOCs), Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.2). The infectivities of the Alpha and Beta variants were significantly lower, as were the infectivities of Gamma.
However, Delta and Lambda variants were significantly higher, as was Epsilon (though that variant is believed to be stamped out). What they found suggests the more infectious the variant, the more resistance it is to vaccine immunity.
IMPORTANT TO UNDERSTAND: Research from Piccoli in 2020 found the receptor binding domain (RBD) of the SARS-CoV-2 S protein is immunodominant, and mutations in this domain can lead to immune evasion. Research from McCallum in 2021 found the mutations in the N-terminal domain (NTD) of the SARS-CoV-2 S protein are associated with the escape neutralization.
These results suggest that the Lambda S is highly infectious and resistant to the vaccine-induced humoral immunity, and the robust resistance of the Lambda S to the vaccine-induced neutralization is determined by a large deletion in the NTD.
What about that large deletion referenced?
Virology experiments found that a large 7-amino-acid deletion, the RSYLTPGD246-253N mutation, does not affect viral infectivity. However, it is responsible for the resistance to the vaccine-induced neutralization as well as an NTD-targeting NAb.
Bottom line: This, and all the other research suggests that Alpha is the key to surviving a longterm pandemic like this. You must be exposed to, and survive, Alpha. Exposure to the parental strain provides significantly higher immunity, significantly less symptomatic response, and fewer rates of hospitalizations. I'd like to see similar studies comparing immunity with Lambda like we've seen previously from Delta and others.
"These observations suggest that acquiring at least two virological features, increased viral infectivity and evasion from antiviral (vaccine) immunity, is pivotal to the efficient spread and transmission in the human population."
We're being outsmarted by a virus, folks. I imagine that's because it doesn't consult it's ideology before it decides how to react. We're going to discuss this more in a live stream today, shortly.
So...
This video was hours ago and internet wasn't enough apparently. But that's okay because I have to provide an update.
I am currently at Andrews AB. Might as well stay in DC area for the night. Have out. Get a rental in the am and head home.
I will be backed up but @RobertBarnes and I are doing a Friday Poll Special.
We will have a lot of drops.
Nate Silver thinks he’s smarter than everybody. He goes in and says this poll is credible, these right-wing pollsters are fake and these left-wing pollsters are great.
He weighted Wedgewood, a FAKE firm, higher than the New York Times, higher than Quantus, higher than Mark Mitchell! This is why his model gets humiliated year after year.
We need a complete overhaul of this industry.
Watch Live 3:00 PM EST — Robert Barnes and Rich Baris discuss in detail bombshell results within the Public Polling Project for Early Spring 2021, and more civil unrest amid the trial of Derek Chauvin for the death of George Floyd.
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Hey guys,
I'm going to pin this here. I've gotten a lot of questions about 1) the hardcover not on other distributors and 2) audiobook.
1) Yes, the hardcover as of now is only available on Amazon.
2. The audiobook has been submitted. It's out of our hands and up to Audible now. It'll just pop up on Amazon when it is available and if I see it first, I'll let you know.
Also, do not forget to leave a review if you liked it. As you can see, there are certain "MAGA" mad at me and just attacking me personally in reviews.
https://www.amazon.com/Burn-Down-Polls-Americans-Really/dp/B0HJRZ7JGR/ref=tmm_hrd_swatch_0
I am going to do a stream today. I had pre-taped and phone interviews all day outside of what wasn't live.
There will be a lot of cool stuff coming out. I will ofc post them here.
But I will do a recap of all this and where I think we are later today. I am just going to the gym to decompress a bit and get the boys something to eat.
I had AI create show thumbnails to illustrate county-level shifts by median age and Hispanics. H/T Elliot Morris for the site tool.
What an EPIC ass-kicking.
That is what a "Betrayal Environment" looks like, a term @RobertBarnes and I coined to warn of impending disaster.
Watching people attempt to "unskew" polls conducted by all walks of this industry—ranging from Nate Cohn at The New York Times to Spencer Kimball at Emerson College to Tim Malloy at Quinnipiac—all to deny Donald Trump's gains against Joe Biden with various voting blocs, is more than a little sad.
The slew of recent polls over two weeks—to include no less than four today alone—have simply confirmed prior findings published from other pollsters who have previously been "unskewed". That includes your's truly and our work at BIG DATA POLL, Mark Penn at Harvard University, Patrick Ruffini at Echelon Insights, and many others.
I'm temped to equate this with an Occam's razor-like situation. But this debate is more about likelihood than simplicity.
Here's the Presidential Vote Preference Trend for Biden v. Trump going back to August 2020. The Public Polling Project did not begin asking the Rematch Question for 2024 until September 2021. However, we can still make some pretty important and interesting observations.