We're allowing hundreds of thousands to pour over the Southern Border from South America, where the Lambda variant is dominant. Keep that in mind when you read the rest of this.
The title of this new paper speaks for itself: "SARS-CoV-2 Lambda variant exhibits higher infectivity and immune resistance"
Notable here, is the case of Chile, where the vaccination rate is relatively high. The percentage who received at least one dose of COVID-19 vaccine was ~60% on June 1, 2021."
However, the new study focuses on vaccination, not natural immunity, and how the Lambda variant is so "proficient in escaping from the antiviral immunity elicited by vaccination."
The same is also true of the Delta variant.
Researchers prepared the viruses pseudotyped with the S proteins of the Lambda variant as well as four variants of concerns (VOCs), Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.2). The infectivities of the Alpha and Beta variants were significantly lower, as were the infectivities of Gamma.
However, Delta and Lambda variants were significantly higher, as was Epsilon (though that variant is believed to be stamped out). What they found suggests the more infectious the variant, the more resistance it is to vaccine immunity.
IMPORTANT TO UNDERSTAND: Research from Piccoli in 2020 found the receptor binding domain (RBD) of the SARS-CoV-2 S protein is immunodominant, and mutations in this domain can lead to immune evasion. Research from McCallum in 2021 found the mutations in the N-terminal domain (NTD) of the SARS-CoV-2 S protein are associated with the escape neutralization.
These results suggest that the Lambda S is highly infectious and resistant to the vaccine-induced humoral immunity, and the robust resistance of the Lambda S to the vaccine-induced neutralization is determined by a large deletion in the NTD.
What about that large deletion referenced?
Virology experiments found that a large 7-amino-acid deletion, the RSYLTPGD246-253N mutation, does not affect viral infectivity. However, it is responsible for the resistance to the vaccine-induced neutralization as well as an NTD-targeting NAb.
Bottom line: This, and all the other research suggests that Alpha is the key to surviving a longterm pandemic like this. You must be exposed to, and survive, Alpha. Exposure to the parental strain provides significantly higher immunity, significantly less symptomatic response, and fewer rates of hospitalizations. I'd like to see similar studies comparing immunity with Lambda like we've seen previously from Delta and others.
"These observations suggest that acquiring at least two virological features, increased viral infectivity and evasion from antiviral (vaccine) immunity, is pivotal to the efficient spread and transmission in the human population."
We're being outsmarted by a virus, folks. I imagine that's because it doesn't consult it's ideology before it decides how to react. We're going to discuss this more in a live stream today, shortly.
I feel like tearing off my clothes and dancing in the rain (snow on Tuesday). Ofc I'm entirely too old to do that. But...
We were SO right.
Here's Snoop, who rapped "F--K Donald Trump" in 2017, now performing at a Trump supporting inauguration party.
Watch Live 3:00 PM EST — Robert Barnes and Rich Baris discuss in detail bombshell results within the Public Polling Project for Early Spring 2021, and more civil unrest amid the trial of Derek Chauvin for the death of George Floyd.
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Kennedy's out there doing gods work.
Crushing hospital incentives to mandate doctors/nurses get covid vaxxed.
RFK Jr whole HHS team💪
BTFOs whole med superstructure🤣
Rest of the admin👎
https://x.com/SecKennedy/status/1951372406968164599?t=giU1xvoiHjQnvmgMHzrS3g&s=19
I wonder sometimes if Trump likes getting his ass kicked nationally and worldwide🤔
He COULD have this success too!!
I worked as a bouncer when I was young (I was 6'1" and 250lbs so avg large but nothing special) and big guys are used to being big and so they get a certain amount of prestige without ever having to prove themselves a threat. I found that if I gave big guys a chance to back down without losing face the vast majority would see the wisdom in that path.
The whole reason Russia has been slow rolling the Ukraine war has been to give Trump an easy out and the stupid arrogant ass cannot see it. I will bet any amount of money that Trump has never in his life been in a real fist fight and yet he is trying to intimidate a man who even though he is half Trump's size he would physically level Trump in a actual fight. And then back that up with Russia having More missiles that are newer technology than the USA.
Like in the movie "WARGAMES" the only way to win is to NOT play the game.
Pray that someone with sense can talk it into Trump...
*I would put money on Putin kicking my ass too, but I ...
TROUBLE IN UTAH: AAG Dhillon DEMANDS VOTER REGISTRATION FILES FROM LT. GOV. DEIDRE
Buhaha. Let the games begin.
Follow this thread: https://x.com/AndrewPiskadlo/status/1951451189746475310
I walk through exactly what DOJ is alleging—and what Utah’s been hiding.
Deidre Henderson has until July 29 to cough up:
Full statewide voter file
Duplicate & invalid registrants
Breakdown of non-citizen, felony, and incompetency flags
Data Utah falsely reported to the feds (263.7% removal discrepancy)
📄 DOJ letter:
All attached
📊 Removal data (EAVS):
Utah’s voter roll removals = 0.8% of total voters
Yet Utah reported removing 45,342 via confirmation notice → actual number: 17,196
(Find them attached)
📜 State law:
Ineligible voters = non-citizens, felons (without rights restored), and institutionalized persons.
Utah reported no categorized data for most counties.
🎭 Memes aside, this is serious:
Utah may be in noncompliance with NVRA, with evidence of systemic reporting fraud to federal agencies.
If DOJ ...
Watching people attempt to "unskew" polls conducted by all walks of this industry—ranging from Nate Cohn at The New York Times to Spencer Kimball at Emerson College to Tim Malloy at Quinnipiac—all to deny Donald Trump's gains against Joe Biden with various voting blocs, is more than a little sad.
The slew of recent polls over two weeks—to include no less than four today alone—have simply confirmed prior findings published from other pollsters who have previously been "unskewed". That includes your's truly and our work at BIG DATA POLL, Mark Penn at Harvard University, Patrick Ruffini at Echelon Insights, and many others.
I'm temped to equate this with an Occam's razor-like situation. But this debate is more about likelihood than simplicity.
Here's the Presidential Vote Preference Trend for Biden v. Trump going back to August 2020. The Public Polling Project did not begin asking the Rematch Question for 2024 until September 2021. However, we can still make some pretty important and interesting observations.