We're allowing hundreds of thousands to pour over the Southern Border from South America, where the Lambda variant is dominant. Keep that in mind when you read the rest of this.
The title of this new paper speaks for itself: "SARS-CoV-2 Lambda variant exhibits higher infectivity and immune resistance"
Notable here, is the case of Chile, where the vaccination rate is relatively high. The percentage who received at least one dose of COVID-19 vaccine was ~60% on June 1, 2021."
However, the new study focuses on vaccination, not natural immunity, and how the Lambda variant is so "proficient in escaping from the antiviral immunity elicited by vaccination."
The same is also true of the Delta variant.
Researchers prepared the viruses pseudotyped with the S proteins of the Lambda variant as well as four variants of concerns (VOCs), Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.2). The infectivities of the Alpha and Beta variants were significantly lower, as were the infectivities of Gamma.
However, Delta and Lambda variants were significantly higher, as was Epsilon (though that variant is believed to be stamped out). What they found suggests the more infectious the variant, the more resistance it is to vaccine immunity.
IMPORTANT TO UNDERSTAND: Research from Piccoli in 2020 found the receptor binding domain (RBD) of the SARS-CoV-2 S protein is immunodominant, and mutations in this domain can lead to immune evasion. Research from McCallum in 2021 found the mutations in the N-terminal domain (NTD) of the SARS-CoV-2 S protein are associated with the escape neutralization.
These results suggest that the Lambda S is highly infectious and resistant to the vaccine-induced humoral immunity, and the robust resistance of the Lambda S to the vaccine-induced neutralization is determined by a large deletion in the NTD.
What about that large deletion referenced?
Virology experiments found that a large 7-amino-acid deletion, the RSYLTPGD246-253N mutation, does not affect viral infectivity. However, it is responsible for the resistance to the vaccine-induced neutralization as well as an NTD-targeting NAb.
Bottom line: This, and all the other research suggests that Alpha is the key to surviving a longterm pandemic like this. You must be exposed to, and survive, Alpha. Exposure to the parental strain provides significantly higher immunity, significantly less symptomatic response, and fewer rates of hospitalizations. I'd like to see similar studies comparing immunity with Lambda like we've seen previously from Delta and others.
"These observations suggest that acquiring at least two virological features, increased viral infectivity and evasion from antiviral (vaccine) immunity, is pivotal to the efficient spread and transmission in the human population."
We're being outsmarted by a virus, folks. I imagine that's because it doesn't consult it's ideology before it decides how to react. We're going to discuss this more in a live stream today, shortly.
Folks, if you don't know what diners, you don't know.
We miss diners and this is Lancer's Diner in Warrington, and it's amazing!
After nearly two years of discipline on issues that cost them the 2024 election, Democrats unleash the CRAZY in Bucks County. Paul Martino, their chief target during what was supposed to be a "discussion", joined to discuss.
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While attacking The New York Times/Siena Poll, a claim treats the leaned partisan composition of a likely-voter sample as evidence of bias against Republicans. In this episode, we test that inference against current party identification, independent leaners, vote preference, the broader political environment in the basic context of thermostat public opinion.
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https://www.simonandschuster.com/books/Burn-It-Down/Rich-Baris/9798895658185
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Watch Live 3:00 PM EST — Robert Barnes and Rich Baris discuss in detail bombshell results within the Public Polling Project for Early Spring 2021, and more civil unrest amid the trial of Derek Chauvin for the death of George Floyd.
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UPDATE: I'm deleting the ones that are over after a day or so to give everyone a chance to go check them out if they haven't already.
Lot of these interviews are pre-recorded. But here are the ones coming up.
On Demand with Jenna Ellis
https://x.com/realjennaellis/status/2103516439814533314
Scott Horton Show
Pre-Record - TBA release (tomorrow I think, but will link here).
Mario Nawfal (Rescheduled for this day)
Saturday, September 26, 2026
7:00 PM (EDT)
Happy Birthday to my GORGEOUS wife!
Fall is my favorite time of the year. It's perfectly fitting that it is when the Lord Blessed the world with @LauraBaris.
Love you, Baby!
P.S. Go out with your friend who basically shares your birthday and don’t let the kids COMPLETELY dominate it.
Watching people attempt to "unskew" polls conducted by all walks of this industry—ranging from Nate Cohn at The New York Times to Spencer Kimball at Emerson College to Tim Malloy at Quinnipiac—all to deny Donald Trump's gains against Joe Biden with various voting blocs, is more than a little sad.
The slew of recent polls over two weeks—to include no less than four today alone—have simply confirmed prior findings published from other pollsters who have previously been "unskewed". That includes your's truly and our work at BIG DATA POLL, Mark Penn at Harvard University, Patrick Ruffini at Echelon Insights, and many others.
I'm temped to equate this with an Occam's razor-like situation. But this debate is more about likelihood than simplicity.
Here's the Presidential Vote Preference Trend for Biden v. Trump going back to August 2020. The Public Polling Project did not begin asking the Rematch Question for 2024 until September 2021. However, we can still make some pretty important and interesting observations.