We're allowing hundreds of thousands to pour over the Southern Border from South America, where the Lambda variant is dominant. Keep that in mind when you read the rest of this.
The title of this new paper speaks for itself: "SARS-CoV-2 Lambda variant exhibits higher infectivity and immune resistance"
Notable here, is the case of Chile, where the vaccination rate is relatively high. The percentage who received at least one dose of COVID-19 vaccine was ~60% on June 1, 2021."
However, the new study focuses on vaccination, not natural immunity, and how the Lambda variant is so "proficient in escaping from the antiviral immunity elicited by vaccination."
The same is also true of the Delta variant.
Researchers prepared the viruses pseudotyped with the S proteins of the Lambda variant as well as four variants of concerns (VOCs), Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.2). The infectivities of the Alpha and Beta variants were significantly lower, as were the infectivities of Gamma.
However, Delta and Lambda variants were significantly higher, as was Epsilon (though that variant is believed to be stamped out). What they found suggests the more infectious the variant, the more resistance it is to vaccine immunity.
IMPORTANT TO UNDERSTAND: Research from Piccoli in 2020 found the receptor binding domain (RBD) of the SARS-CoV-2 S protein is immunodominant, and mutations in this domain can lead to immune evasion. Research from McCallum in 2021 found the mutations in the N-terminal domain (NTD) of the SARS-CoV-2 S protein are associated with the escape neutralization.
These results suggest that the Lambda S is highly infectious and resistant to the vaccine-induced humoral immunity, and the robust resistance of the Lambda S to the vaccine-induced neutralization is determined by a large deletion in the NTD.
What about that large deletion referenced?
Virology experiments found that a large 7-amino-acid deletion, the RSYLTPGD246-253N mutation, does not affect viral infectivity. However, it is responsible for the resistance to the vaccine-induced neutralization as well as an NTD-targeting NAb.
Bottom line: This, and all the other research suggests that Alpha is the key to surviving a longterm pandemic like this. You must be exposed to, and survive, Alpha. Exposure to the parental strain provides significantly higher immunity, significantly less symptomatic response, and fewer rates of hospitalizations. I'd like to see similar studies comparing immunity with Lambda like we've seen previously from Delta and others.
"These observations suggest that acquiring at least two virological features, increased viral infectivity and evasion from antiviral (vaccine) immunity, is pivotal to the efficient spread and transmission in the human population."
We're being outsmarted by a virus, folks. I imagine that's because it doesn't consult it's ideology before it decides how to react. We're going to discuss this more in a live stream today, shortly.
Opium Production in Afghanistan Cratered Following U.S. Withdrawal | Side Stories on Between the Numbers
Former CIA Officer John Kiriakou recently told Tucker Carlson a story about opium production in Afghanistan.
It skyrocketed after the invasion and cratered once the U.S. withdrew. The U.S. government has a long, dark and ugly history of selling drugs.
The One-Two Combo that Knocked Out MAGA + What's the Difference Between Ignorance and Stupidity?
#Epstein set it up with a left jab... POP 🤛! Iran came with the big overhand right... and POW 👊!
Down went #MAGA. Count to 10. Hell, count to 100. It's over.
Watch Live 3:00 PM EST — Robert Barnes and Rich Baris discuss in detail bombshell results within the Public Polling Project for Early Spring 2021, and more civil unrest amid the trial of Derek Chauvin for the death of George Floyd.
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While I slightly feel bad, it had to be done.
We wanted to change out the microwave hood for a REAL hood because we cook with natural gas and entirely too much. The exhaust is not sufficient.
So, my son and I remove it and...
Tada! Mockingbird nest. As in, in the hood exhaust pipe on TOP of the microwave.
Two or three of the poor little bastards met their ends via the exhaust fan. Chop, chop. Hot, hot. The last man standing was taken behind the property by the easement and left for the hawks or owl, whichever will undoubtedly make short order of the little dude.
Thank God we really do not use a microwave because it's disgusting. I need to better, more permanently block the little basards from getting into these vents. This is the second time birds have gotten in and made nests because the builder didn't put the correct vent cage on.
I also noticed the cheap SOBs didn't TILE all the way up to the exhaust. Hope they spent the money on the 8 TILES they cheated me on.
Huh, anyhoo...
...
Ok, looks like Robert and I cannot do "What Are the Odds?" tonight, so instead...
We will do one on July 1 before I go to DC for the celebrations.
I will almost certainly pop on for a bit later but instead, let's do it tomorrow because there are primaries we can cover and we can save the content for July 1.
Lot of traveling this and next month all the way up to the 1776 Law Center conference. Looks like Bedminster too on July 18.
But we'll figure it out. After that conference, it's almost certainly Minnesota next.
Watching people attempt to "unskew" polls conducted by all walks of this industry—ranging from Nate Cohn at The New York Times to Spencer Kimball at Emerson College to Tim Malloy at Quinnipiac—all to deny Donald Trump's gains against Joe Biden with various voting blocs, is more than a little sad.
The slew of recent polls over two weeks—to include no less than four today alone—have simply confirmed prior findings published from other pollsters who have previously been "unskewed". That includes your's truly and our work at BIG DATA POLL, Mark Penn at Harvard University, Patrick Ruffini at Echelon Insights, and many others.
I'm temped to equate this with an Occam's razor-like situation. But this debate is more about likelihood than simplicity.
Here's the Presidential Vote Preference Trend for Biden v. Trump going back to August 2020. The Public Polling Project did not begin asking the Rematch Question for 2024 until September 2021. However, we can still make some pretty important and interesting observations.