We're allowing hundreds of thousands to pour over the Southern Border from South America, where the Lambda variant is dominant. Keep that in mind when you read the rest of this.
The title of this new paper speaks for itself: "SARS-CoV-2 Lambda variant exhibits higher infectivity and immune resistance"
Notable here, is the case of Chile, where the vaccination rate is relatively high. The percentage who received at least one dose of COVID-19 vaccine was ~60% on June 1, 2021."
However, the new study focuses on vaccination, not natural immunity, and how the Lambda variant is so "proficient in escaping from the antiviral immunity elicited by vaccination."
The same is also true of the Delta variant.
Researchers prepared the viruses pseudotyped with the S proteins of the Lambda variant as well as four variants of concerns (VOCs), Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.2). The infectivities of the Alpha and Beta variants were significantly lower, as were the infectivities of Gamma.
However, Delta and Lambda variants were significantly higher, as was Epsilon (though that variant is believed to be stamped out). What they found suggests the more infectious the variant, the more resistance it is to vaccine immunity.
IMPORTANT TO UNDERSTAND: Research from Piccoli in 2020 found the receptor binding domain (RBD) of the SARS-CoV-2 S protein is immunodominant, and mutations in this domain can lead to immune evasion. Research from McCallum in 2021 found the mutations in the N-terminal domain (NTD) of the SARS-CoV-2 S protein are associated with the escape neutralization.
These results suggest that the Lambda S is highly infectious and resistant to the vaccine-induced humoral immunity, and the robust resistance of the Lambda S to the vaccine-induced neutralization is determined by a large deletion in the NTD.
What about that large deletion referenced?
Virology experiments found that a large 7-amino-acid deletion, the RSYLTPGD246-253N mutation, does not affect viral infectivity. However, it is responsible for the resistance to the vaccine-induced neutralization as well as an NTD-targeting NAb.
Bottom line: This, and all the other research suggests that Alpha is the key to surviving a longterm pandemic like this. You must be exposed to, and survive, Alpha. Exposure to the parental strain provides significantly higher immunity, significantly less symptomatic response, and fewer rates of hospitalizations. I'd like to see similar studies comparing immunity with Lambda like we've seen previously from Delta and others.
"These observations suggest that acquiring at least two virological features, increased viral infectivity and evasion from antiviral (vaccine) immunity, is pivotal to the efficient spread and transmission in the human population."
We're being outsmarted by a virus, folks. I imagine that's because it doesn't consult it's ideology before it decides how to react. We're going to discuss this more in a live stream today, shortly.
On "What Are The Odds?" with Baris and Baris on Monday, @RobertBarnes detailed four determining factors that have been predictive in midterms outcomes for the U.S. Senate.
"So on paper, the Senate should not be up for grabs. And when two of these four factors that I'll identify are not present in the Senate election in the midterms, then in fact eighty percent of the time the incumbent party does not lose four or more seats, and is often as likely to gain seats as it is to lose seats—when the map looks like this and when two of these four factors are not present."
Pre-Order Burn It Down 🔥🔥🔥: https://www.simonandschuster.com/books/Burn-It-Down/Rich-Baris/9798895658161
The first copies arrived and we unboxed them!
It's now clear "Burn It Down: What The Polls Say Young Americans Really Want" by Rich Baris THE PEOPLE'S PUNDIT & Joshua Lisec has become THE central theme and must-read book of the 2026 #midterms, and that won't change anytime soon.
BIG DATA POLL has exclusive data from decades of trend-tracking and uncomfortable question-asking, and it all points to the same conclusion. Imminent systemic collapse is coming and we must choose: It's either MAGA or Mamdani!
Young people believe systems are rigged and the old order feeds itself at their expense. They don’t want to reform the system; they want to Burn It Down! 🔥 🔥 🔥 Pre-Order NOW https://amazon.com/dp/B0GV4PT4LB
UPDATE: I got bumped before I could get back to the gym. Oh well, still 14 on the Best Seller. Keep pushing!
"Burn It Down: What The Polls Say Young Americans Really Want" by Rich Baris THE PEOPLE'S PUNDIT & Joshua Lisec has become THE central theme and must-read book of the 2026 #midterms, and that won't change anytime soon.
BIG DATA POLL has exclusive data from decades of trend-tracking and uncomfortable question-asking, and it all points to the same conclusion. Imminent systemic collapse is coming and we must choose: It's either MAGA or Mamdani!
Young people believe systems are rigged and the old order feeds itself at their expense. They don’t want to reform the system; they want to Burn It Down! 🔥 🔥 🔥 Pre-Order NOW https://amazon.com/dp/B0GV4PT4LB
Watch Live 3:00 PM EST — Robert Barnes and Rich Baris discuss in detail bombshell results within the Public Polling Project for Early Spring 2021, and more civil unrest amid the trial of Derek Chauvin for the death of George Floyd.
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Told you guys I'd talk to anyone!
Almost certainly going to take some shit for this, but oh well!
Viva veritas, folks!
The Babylon Bee - State Of Massachusetts Declared Incompetent By Reason Of Insanity:
https://babylonbee.com/news/state-of-massachusetts-declared-incompetent-by-reason-of-insanity/
Watching people attempt to "unskew" polls conducted by all walks of this industry—ranging from Nate Cohn at The New York Times to Spencer Kimball at Emerson College to Tim Malloy at Quinnipiac—all to deny Donald Trump's gains against Joe Biden with various voting blocs, is more than a little sad.
The slew of recent polls over two weeks—to include no less than four today alone—have simply confirmed prior findings published from other pollsters who have previously been "unskewed". That includes your's truly and our work at BIG DATA POLL, Mark Penn at Harvard University, Patrick Ruffini at Echelon Insights, and many others.
I'm temped to equate this with an Occam's razor-like situation. But this debate is more about likelihood than simplicity.
Here's the Presidential Vote Preference Trend for Biden v. Trump going back to August 2020. The Public Polling Project did not begin asking the Rematch Question for 2024 until September 2021. However, we can still make some pretty important and interesting observations.